Primary Sclerosing Cholangitis Market Forecast to 2025: Top Companies, Trends & Growth Factors and Trend

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Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a liver disorder that causes bile duct inflammation and scarring (fibrosis). These ducts are tubes that allow the liver's fluids (bile) to travel through the colon, allowing fat breakdown to take place. This disease predominantly affects men between the age of 25 and 40 years. The damage to the ducts causes accumulation of bile acids, essential components of bile to build up in the liver leading to liver tissue damage, portal hypertension (high blood pressure in the vessels connecting the liver and the gut), and liver failure, and may increase the risk of liver cancer.

Optimistic Global Primary Sclerosing Cholangitis Market Scenario:

Current medicinal interventions, such as ursodeoxycholic acid, improve liver enzymes, according to a study published in the Gastroenterology and Hepatology Journal in 2016. It does not, however, stop PSC from progressing or lower the chance of recurrence. As a result, the lack of approved medications to treat the ailment in clinical practice is a stumbling block to the global primary Primary Sclerosing Cholangitis Market growth. 

These prospective compounds would be among the first to receive regulatory approval for this condition if they make it through the advanced clinical trials phase (i.e. Phase 3) and win regulatory approval. Furthermore, the majority of patients live in developed economies such as Europe and North America, where diagnosis rates and affordability are generally higher than in emerging economies such as the Asia Pacific, Primary Sclerosing Cholangitis Market resulting in a higher rate of adoption of novel products with significantly higher yearly costs.

However, the withdrawal of prospective therapeutic compounds from late-stage clinical trials has limited the availability of effective treatment, forcing patients to turn to bile acid sequestrants, antibiotics, antihistamines, opioid antagonists, and ursodeoxycholic acid as alternatives (UDCA). 

Acorda Therapeutics, Inc., Conatus Pharmaceuticals, Inc., NGM Biopharmaceuticals, Gilead Sciences, Sirnaomics, Inc., Dr. Falk Pharma GmbH, Inc., Intercept Pharmaceuticals, Inc., Allergan Plc., Shire Plc., Durect Corporation, Inc., and Shenzhen HighTide Biopharmaceutical Ltd. are among the major players in the global Primary Sclerosing Cholangitis Market.

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